MetaGO result for job id PF10048

User Input

>UniRef100_A0A176S3V4/1-149 (149 residues)
MANPNTMVNTALASVLAMGLGTTSTNVLAGKPGFEKCAGIVKAGMNACGTSKHGCGGVAK
TDADSEEWIYLPKGTCEKIVNATLKQEADDAQAQVENWEKCAGIVKVGMNACGTSKHGCG
GAAKTDADPEEWIMVPQGTCDKIVGGITK

Download query sequence and structure

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	2bw3A	0.46	4.70	0.060	0.745	Download
2	3bkkA	0.46	4.80	0.056	0.738	Download
3	1r4lA3	0.46	4.87	0.049	0.738	Download
4	1j36A	0.45	5.19	0.047	0.772	Download
5	1e6vA	0.45	4.72	0.062	0.752	Download
6	2rjqA1	0.37	5.14	0.035	0.644	Download
7	3sqgA1	0.35	5.57	0.028	0.685	Download
8	2c6fA2	0.33	5.81	0.008	0.631	Download
9	2hxsA	0.33	4.95	0.093	0.584	Download
10	3lm7A	0.33	5.68	0.088	0.638	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term

Cscore^GO

Name

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.13,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:2000170	0.01	positive regulation of peptidyl-cysteine S-nitrosylation
GO:1903597	0.01	negative regulation of gap junction assembly
GO:1902033	0.01	regulation of hematopoietic stem cell proliferation
GO:1900086	0.01	positive regulation of peptidyl-tyrosine autophosphorylation
GO:0071838	0.01	cell proliferation in bone marrow
GO:0061098	0.01	positive regulation of protein tyrosine kinase activity
GO:0060218	0.01	hematopoietic stem cell differentiation
GO:0060047	0.01	heart contraction
GO:0055114	0.01	oxidation-reduction process
GO:0051289	0.01	protein homotetramerization

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.08,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0005576	0.03	extracellular region
GO:0070062	0.01	extracellular exosome
GO:0016020	0.01	membrane
GO:0009897	0.01	external side of plasma membrane
GO:0005768	0.01	endosome
GO:0005764	0.01	lysosome
GO:0005615	0.01	extracellular space

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.14,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Reference:

Chengxin Zhang, Peter L Freddolino, and Yang Zhang. (2018) MetaGO: A Structure and Protein-Protein Interaction Network Based Pipeline for Automated Protein Function Annotations. Journal of Molecular Biology.

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