MetaGO result for job id PF07637

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>UniRef100_H8MY63/54-547 (494 residues)
DPGRVTLHRLNRAEYNNTVRDLLGETGSPASSFPPDDHGFGFDNNADVLSMSPLLMEKYS
HAAEALVEAAWTRGAFNACGLDPAQPEACARELLKTFARRAWRRPVTQEEVERLVAFVAL
ARQQGDAPEVGVKLALRAVLVSPHFLFRVELDPAPTSTVPHAVSDLELASRLSYFLWSSM
PDEALLQAAEGGHLHEPEVLEAQVRRMLADPKARALVDNFAGQWLYTRALDFSQPESRYG
FDEPLREAMRQEMQLVFQEFVTGDHRLKDLLDAPFTYVNDRLASHYGLPKPRTPAMTRVE
LKDHPERAGLFGKGALLTVTANPDRTSPVKRGVWVLEQLLCKGPPPPPPDAGGLAPAVDP
TLNIKARMAQHRVDPTCSGCHTLMDPLGFGMENFDPVGRWRTKEEGGAVVDPSGELPGGK
AFNGVAEMRAVVKQDPDLSACMTRHLLTYALGRGAEEQDRCTVRDISQQAETRGGRLTDY
ILAIVRSDAFLQRR

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Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	5ikyA	0.39	7.38	0.052	0.646	Download
2	3zyvA	0.39	7.40	0.041	0.638	Download
3	2z8zA	0.38	7.15	0.033	0.609	Download
4	2quaA	0.38	7.13	0.051	0.603	Download
5	5dotA	0.38	7.32	0.037	0.607	Download
6	3dx4A	0.37	7.71	0.064	0.644	Download
7	1go7P	0.32	6.68	0.040	0.490	Download
8	1dgjA2	0.30	7.43	0.034	0.500	Download
9	1q2lA2	0.26	7.20	0.040	0.411	Download
10	1w96A1	0.26	7.61	0.050	0.439	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0051540	0.05	metal cluster binding
GO:0050662	0.05	coenzyme binding
GO:0046914	0.05	transition metal ion binding
GO:0016726	0.05	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
GO:0000166	0.05	nucleotide binding
GO:0016727	0.02	oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.13,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0046110	0.04	xanthine metabolic process
GO:0006145	0.04	purine nucleobase catabolic process

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.08,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0005829	0.03	cytosol
GO:0005777	0.03	peroxisome
GO:0005615	0.02	extracellular space
GO:0005576	0.02	extracellular region

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.14,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Reference:

Chengxin Zhang, Peter L Freddolino, and Yang Zhang. (2018) MetaGO: A Structure and Protein-Protein Interaction Network Based Pipeline for Automated Protein Function Annotations. Journal of Molecular Biology.

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